Strahlentherapie: Risikoorgane und Konturierung – Page 6 – On-Line Praktikum Medizinische Strahlenphysik

Tolerance Doses

1 / 7

What does TD50/5 = 66.5 Gy mean?

The maximum tolerance dose to which 50% of the organ in 5 fractions may be exposed is 66.5 Gy

The tolerance dose at which 50% of people will show side effects in 5 years is 66.5 Gy

The tolerance dose at which 5% of people will show side effects in 50 years is 66.5 Gy

2 / 7

What does V20 < 35% mean?

20% of the organ volume may receive a maximum of 35% of the total dose

35% of the organ volume must remain below 20 Gy

3 / 7

In which organs does the volume effect play a particularly important role in the tolerance doses?

in serial organized organs

in parallel organized organs

4 / 7

On which research publications are the tolerance doses based?

Emami et al.

Schmidt et al.

Marks et al.

5 / 7

Which tolerance doses were taken into account in the Emami paper in 1991?

Indication of TD5/5 and TD50/5 for 1/3, 2/3 and complete organ

Indication of TD5/5, TD50/5 and TD 100/5 for the complete organs

Indication of TD5/5 and TD50/5 for 5% of the organ, 50% of the organ and the complete organ

6 / 7

When did QUANTEC (Marks et al) attempt to describe the normal tissue complication probability (NTCP) in dependence of the dose and the irradiated volume using mathematical models?

1990

2000

2010

2020

7 / 7

What do you have to consider while using the published tolerance doses in the clinic?

There are new radiation techniques since the studies on which the publications are based

Individual weighing of benefits and risks of the dose for the patient

Nothing. They can always be applied 1:1

Your score is